NORMALIZATION OF IMMUNE-RESPONSE AND PHOSPHOINOSITIDE FATTY-ACID COMPOSITION OF PERIPHERAL-BLOOD LYMPHOCYTES IN AN ALCOHOLIC PATIENT AFTER ALCOHOL ABSTINENCE

Authors
STEFANINI GF CASTELLI E FOSCHI FG MARSIGLI L ADDOLORATO G CELADON M BIAGI PL BORDONI A GASBARRINI G HRELIA S
Citation
Gf. Stefanini et al., NORMALIZATION OF IMMUNE-RESPONSE AND PHOSPHOINOSITIDE FATTY-ACID COMPOSITION OF PERIPHERAL-BLOOD LYMPHOCYTES IN AN ALCOHOLIC PATIENT AFTER ALCOHOL ABSTINENCE, Biochemistry and molecular biology international, 39(2), 1996, pp. 359-367
Citations number
19
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
39
Issue
2
Year of publication
1996
Pages
359 - 367
Database
ISI
SICI code
1039-9712(1996)39:2<359:NOIAPF>2.0.ZU;2-D
Abstract
After 10 months of alcohol abstinence a malnourished alcoholic patient improved his nutritional status. The analysis of peripheral blood lym phocyte response to mitogenic stimulation with the antibody anti-CD3 a nd of the fatty acid composition of the (poly)-phosphoinositide fracti on derived from lymphocytes revealed: 1) a similar [H-3]-thymidine upt ake as in control (non-drinker) subjects; 2) a similar relative molar content of the main fatty acids in the (poly)-phosphoinositides as in control subjects. Alcohol abstinence can normalize both the parameters , which are greatly altered during alcohol abuse. This suggests a link between nutritional status and lymphocyte responsiveness via phosphoi nositide fatty acid composition.