EXCRETION OF KETOBEMIDONE IN HUMAN BREAST-MILK

The excretion of ketobemidone into human breast milk was investigated in three women who obtained ketobemidone as postoperative pain relief after Cesarean section and two women premedicated with 5 ms of ketobem idone before currettage after delivery. The highest observed concentra tion of ketobemidone in breast milk was 36 ng/ml three hours after adm inistration, and 4-7 hours after administration the concentration was 3-5 fold that in maternal plasma. It could be estimated that the newbo rn will be exposed to less than 2 mu g of ketobemidone during the firs t 24 hours.