NEW ANTHRACYCLINE DISACCHARIDES - SYNTHESIS OF L-DAUNOSAMINYL-ALPHA(1-]4)-2-DEOXY-L-RHAMNOSYL AND OF L-DAUNOSAMINYL-ALPHA(1-]4)-2-DEOXY-L-FUCOSYL DAUNORUBICIN ANALOGS

Authors
ANIMATI F ARCAMONE F BERETTONI M CIPOLLONE A FRANCIOTTI M LOMBARDI P
Citation
F. Animati et al., NEW ANTHRACYCLINE DISACCHARIDES - SYNTHESIS OF L-DAUNOSAMINYL-ALPHA(1-]4)-2-DEOXY-L-RHAMNOSYL AND OF L-DAUNOSAMINYL-ALPHA(1-]4)-2-DEOXY-L-FUCOSYL DAUNORUBICIN ANALOGS, Journal of the Chemical Society. Perkin transactions. I, (12), 1996, pp. 1327-1329
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
12
Year of publication
1996
Pages
1327 - 1329
Database
ISI
SICI code
0300-922X(1996):12<1327:NAD-SO>2.0.ZU;2-1
Abstract
The synthesis of the new disaccharide anthracyclines 20, 21, 24 and 25 , where the daunosamine moiety is separated from the aglycone by eithe r a rhamnose or a fucose residue, performed following a convergent pro cedure, gives insight into the configurational requirement of the firs t sugar residue and opens the way to a new class of antitumour anthrac yclines.