EFFECTS OF INTERSTIMULUS-INTERVAL ON SCALP TOPOGRAPHIES EVOKED BY NOXIOUS SURAL NERVE-STIMULATION

The amplitude of the late pain-related negative-positive peak complex, which we have labeled SP3 (134-150 ms) and SP6 (277-331 ms), respecti vely, increased with increasing interstimulus interval (ISI). This con trasts with the nociceptive spinal withdrawal reflex and subjective pa in rating data, which implied that nociceptive somatosensory processes were unaffected by ISI at stimulus levels that were well within the p ain range. A scalp topographic analysis strongly suggested that none o f the brain areas responsible for SP3 or SP6 are involved exclusively in nociception. We also observed a pain-related positive potential app roximately 161-177 ms following sural nerve stimulation that has not b een reported by others. A dipole source localization analysis and the effects of ISI and stimulus intensity on this potential suggest that i t is generated by the response of primary somatosensory cortex neurons to inputs arising from the innocuous peripheral afferents and that th is response is inhibited by noxious inputs.