Three cases of neurogenic muscular hypertrophy are reported. First cas
e presented a hypertrophy of one calf following SI radiculopathy; the
second had a hypertrophy of tibialis anterior muscle, five years after
a compressive injury of the common peroneal nerve. The third case is
a global hypertrophy of leg muscles after intensive care or legionella
neuropathy. Previous cases of the literature are reviewed and the var
ious pathophysiological hypothesis are considered. Among these hypothe
sis, the role of abnormal electrophysiological activities in most prev
ious cases, as well as in ours (namely complex repetitive discharges a
nd fasciculations), seems the most consistent.