AZELASTINE REDUCES HISTAMINE-INDUCED SWELLING OF NASAL-MUCOSA

In a monocentric placebo-controlled double-blind study with two-period cross-over the anti-obstructive effect of azelastine nasal spray was evaluated, Nasal provocation with histamine or specific allergen respe ctively was performed before the pollen season in 28 patients with a h istory of seasonal allergic rhinitis. Efficacy was documented by rhino manometry, acoustic rhinometry, rhinoscopy and symptom score. Acoustic rhinometry showed a statistically significant lesser decrease in nasa l cavity volume in favour of azelastine after histamine provocation (p < 0.05). Reduction in nasal flow as determined by rhinomanometry conf irmed this tendency (p < 0.1) after allergen provocation. The analysis of the patients' symptom scores clearly indicated the superior effica cy of azelastine as compared to placebo, especially for nasal obstruct ion after provocation with both histamine (p = 0.005) and allergen (p < 0.02).