SYNTHESIS OF -ALPHA,6-ALPHA)-6-AMINO-3-AZABICYCLO[3.1.0]HEXANE, A NOVEL ACHIRAL DIAMINE

Authors
BRIGHTY KE CASTALDI MJ
Citation
Ke. Brighty et Mj. Castaldi, SYNTHESIS OF -ALPHA,6-ALPHA)-6-AMINO-3-AZABICYCLO[3.1.0]HEXANE, A NOVEL ACHIRAL DIAMINE, Synlett, (11), 1996, pp. 1097
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
11
Year of publication
1996
Database
ISI
SICI code
0936-5214(1996):11<1097:SO-AN>2.0.ZU;2-A
Abstract
Synthesis of (1 alpha,5 alpha,6 alpha)-6-amino-3-azabicyclo[3.1.0]hexa ne is described. Ethyl diazoacetate cycloaddition to a pyrroline or ma leimide derivative provides the azabicyclohexyl system; amine introduc tion is then effected using a modified Curtius rearrangement.