EFFICIENT KINETIC RESOLUTION OF 2-BENZENESULFONYLCYCLOPENTANONE DERIVATIVES

Authors
MAGUIRE AR KELLEHER LL FERGUSON G
Citation
Ar. Maguire et al., EFFICIENT KINETIC RESOLUTION OF 2-BENZENESULFONYLCYCLOPENTANONE DERIVATIVES, Journal of molecular catalysis. B, Enzymatic, 1(3-6), 1996, pp. 115-126
Citations number
30
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. B, Enzymatic → ACNP
ISSN journal
13811177
Volume
1
Issue
3-6
Year of publication
1996
Pages
115 - 126
Database
ISI
SICI code
1381-1177(1996)1:3-6<115:EKRO2D>2.0.ZU;2-P
Abstract
Efficient kinetic resolution of 2-benzenesulfonylcyclopentanones 1, be aring 3-alkyl, 3-aryl, or 3-benzyl substituents, has been achieved by bakers' yeast mediated reduction. With the unsubstituted 2-benzenesulf onylcyclopentanone 1a, efficient asymmetric reduction to form (1S,2R)- cis-2-benzenesulfonylcyclopentanol 2a is observed under the same condi tions. Excellent enantioselectivities (up to > 95% eel are obtained.