EFFECTS ON UDP GLUCURONOSYL TRANSFERASE, GLUTATHIONE TRANSFERASE, DT-DIAPHORASE AND GLUTATHIONE-REDUCTASE ACTIVITIES IN RAINBOW-TROUT LIVERAFTER LONG-TERM EXPOSURE TO PCB

In the present study, long-term exposure to PCB resulted in marked ind uction of the xenobiotic biotransformation enzymes UDP glucuronosyl tr ansferase, glutathione transferase and DT-diaphorase (measured as mena dione reductase and DCPIP reductase) in rainbow trout 15 or 20 weeks p ost-injection during the experimental period. The increase of the phas e II enzymes were paralleled by a marked increase of the glutathione r eductase activity. These results indicate that prolonged exposure to P CB results in increased production of organo-radicals. Copyright (C) 1 996 Elsevier Science Ltd.