Re. Steinpreis et al., THE EFFECTS OF RACLOPRIDE ON VACUOUS JAW MOVEMENTS IN RATS FOLLOWING ACUTE ADMINISTRATION, Physiology & behavior, 60(1), 1996, pp. 253-256
Classic neuroleptics produce a syndrome of vacuous jaw movements in ra
ts, whereas atypical neuroleptics like clozapine do not. The present s
tudy compared the effects of repeated administration of raclopride, cl
ozapine, haloperidol, or vehicle on vacuous jaw movements in rats over
a 4-week period. Rats received an IP injection of drug once a day. On
days 1, 8, 15, and 29 the rats were observed for a 5-min period by tw
o trained observers who recorded their vacuous jaw movements. The dose
-response curves at which each drug produced vacuous jaw movements are
presented and discussed in terms of their predictive capabilities of
early onset extrapyramidal side effects.