SYNTHESIS OF WATER-SOLUBLE BIOLOGICALLY-ACTIVE PHENOL (OR CATECHOL) CONTAINING COPOLYMERS OF N-VINYL-2-PYRROLIDONE

Water-soluble N-vinyl-2-pyrrolidone (VP) copolymers containing phenol (or catechol) groups in the side chains were synthesized by reactions of copolymers of VP and crotonic acid (CA) with p-aminophenol and by r eaction of p-nitrophenyl ester groups containing VP-CA copolymers with dopamine, It was established that phenol (or catechol) containing mul tiunit VP copolymers (which were characterized by GPC, viscometry, UV, IR and H-1 NMR spectroscopy) exhibit immunostimulating activity. In a ddition, the phenol-containing copolymers exhibit antitumor activity. The VP-CA-p-crotonoylaminophenol terpolymer can be used as a macromole cular carrier in the synthesis of a carcinogen-polymer antigen: a poly meric azo derivative of beta-naphthylamine.