FEASIBILITY, PSYCHOMETRIC PERFORMANCE, AND STABILITY ACROSS MODES OF ADMINISTRATION OF THE CARES-SF

Background: The primary objective was to investigate the validity and reliability of the Cancer Rehabilitation Evaluation System-Short Form (the CARES-SF) as a quality of life instrument in clinical trials [10] . Patients and methods: A heterogeneous sample of 485 cancer patients completed the CARES-SF before treatment (T1), one month later (T2), an d three months following T2 (T3). At T3 the patients completed the que stionnaire either by mail, in a telephone interview, or in the clinic. A sub-sample of patients completed the CARES-SF a fourth time (T4) on e week following T3, for purposes of test-retest reliability estimatio n. Results: On average, the CARES-SF required 11 minutes for completio n and could be completed by 90% of the patients without assistance. Ho wever, 82% of the patients reported difficulty with at least one item. Multitrait scaling analysis and factor analysis generally confirmed t he hypothesized scale structure. Internal consistency reliability coef ficients exceeded the 0.70 criterion for four of six multi-item scales . The test-retest reliability coefficients of the six scales were abov e 0.70. No systematic differences were found in the psychometrics of t he CARES-SF across administration conditions. In the mail condition th e proportion of missing items was significantly higher, and patients r eported having significantly more problems than in both the telephone and in-clinic condition. According to expectation, selective scales di stinguished clearly between patients differing in disease stage, perfo rmance status, treatment modality and tumor response. Additionally, se lective scales were responsive to changes in health status over time. Conclusion: These results lend support to the reliability and validity of the CARES-SF in assessing the quality of life of patients with can cer. At the same time, efforts to refine the questionnaire are recomme nded.