HUNGER SENSATION IN PATIENTS WITH COMPENSATED AND UNCOMPENSATED TYPE-1 AND TYPE-2 DIABETES-MELLITUS

Objective: Diabetic patients (DP) refer increased hunger sensation (HS ) when hyperglycemic but not yet ketogenic. As HS shows a within-day ( ultradian cyclicity) and intra-day (circadian cyclicity) repetitivity, ifs recursive pattern was investigated in patients with type 1 and ty pe 2 diabetes mellitus (DM) in compensated and uncompensated metabolic stage. Method: HS was approached in its cyclic structure by means of spectral analysis (SA), and in its circadian rhythmicity by means of S ingle Cosinor analysis (SCA) applied to self-rated scores of HS given every 30 min to their HS (orexigram) by DP. Results: Exaggerated perip randial, interprandial, and/or nocturnal peaks of HS were seen in the orexigram of both the type I and type II DP. Specific alterations in H S periodogram were detected, structurally denoting a relative prevalen ce of the ultradian components along with the deamplification and loss of the circadian harmonics. Discussion: The increase of HS (hyperorex ia) in nonketotic DM may be formally attributed to a mechanism of freq uency multiplication and amplitude demodulation in the multifrequency bioperiodic structure which physiologically regulates the recursive pa ttern to the daily HS in human beings. (C) 1996 by John Wiley and Sons , Inc.