EVALUATION OF THE 5-YEAR REVIEW OF NEGATIVE CERVICAL SMEARS IN PATIENTS WITH HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESIONS

Federal regulations require laboratories to re-examine negative cervic al smears from the 5 yr preceding a diagnosis of high-grade squamous i ntraepithelial lesion (HSIL) or carcinoma. To assess the value of this regulation as a quality assurance measure, we evaluated the previous cervical smears from 47 patients with a diagnosis of HSIL rendered dur ing a 9-mo period. Fifteen patients had a total of 24 previous smears initially reported as squamous intraepithelial lesions (SIL). The rema ining 32 patients had a total of 58 smears thar carried a diagnosis le sser than SIL. Upon re-screening 22/58 (38%) smears, from 16 patients, were upgraded to SIL (8 low grade, 14 high grade). Underdiagnosed SIL was detected in seven (44%) patients with the I-yr review, 12 (75%) w ith the 2-yr review, 15 (94%) with the 3-yr review, and 16 (100%) with the 5-yr review. The authors conclude that the negative smear review is a beneficial quality assurance and teaching method that may lead to quality improvement. A 3-yr retrospective review is effective and det ects 94% of the undercalls. (C) 1996 Wiley-Liss, Inc.