EFFECTS OF CYCLOSPORINE AND SOMATOSTATIN ON LIVER-REGENERATION AFTER PARTIAL-HEPATECTOMY IN RATS

The major hepatic reaction which occurs in response to degeneration or partial loss of the liver is compensatory hyperplasia. After finding out that hemodynamic factors have no influence in hepatic regeneration , the investigations have been focused on some trophic factors which h ave been found in the blood and which have been believed to provide th e basic control of regeneration. In our controlled experimental study we have tried to evaluate the effects on hepatic regeneration of cyclo sporin and somatostatin which are known to act on the hepatic regenera tion ability or which are thought to have effects on regeneration beca use of their mechanism of action. For the purpose of evaluating the re generative response findings like the weight of the regenerated liver, mean Ag nuclear organizer region (AgNOR) number, the mitosis index, c ells with double nuclei and hyperchromatic nucleus were taken into con sideration. The results of the cyclosporin group were higher than of t he controls, but there was no statistically significant difference bet ween them. In the somatostatin group, an inhibition of regeneration re lated to the dose and to the duration at the beginning and a delayed a ugmentation of the regeneration rate due to the withdrawal of the drug were observed. Values of AgNOR were significantly higher compared to the control group on the 5th day postoperatively, while the liver weig ht was lower on the 1st day (p less than or equal to 0.05).