M. Kapan et al., EFFECTS OF CYCLOSPORINE AND SOMATOSTATIN ON LIVER-REGENERATION AFTER PARTIAL-HEPATECTOMY IN RATS, European surgical research, 28(4), 1996, pp. 262-269
The major hepatic reaction which occurs in response to degeneration or
partial loss of the liver is compensatory hyperplasia. After finding
out that hemodynamic factors have no influence in hepatic regeneration
, the investigations have been focused on some trophic factors which h
ave been found in the blood and which have been believed to provide th
e basic control of regeneration. In our controlled experimental study
we have tried to evaluate the effects on hepatic regeneration of cyclo
sporin and somatostatin which are known to act on the hepatic regenera
tion ability or which are thought to have effects on regeneration beca
use of their mechanism of action. For the purpose of evaluating the re
generative response findings like the weight of the regenerated liver,
mean Ag nuclear organizer region (AgNOR) number, the mitosis index, c
ells with double nuclei and hyperchromatic nucleus were taken into con
sideration. The results of the cyclosporin group were higher than of t
he controls, but there was no statistically significant difference bet
ween them. In the somatostatin group, an inhibition of regeneration re
lated to the dose and to the duration at the beginning and a delayed a
ugmentation of the regeneration rate due to the withdrawal of the drug
were observed. Values of AgNOR were significantly higher compared to
the control group on the 5th day postoperatively, while the liver weig
ht was lower on the 1st day (p less than or equal to 0.05).