CYCLIC VARIATIONS OF SR-233377 (WIN-33377) AND EFFECTS ON ANTITUMOR-ACTIVITY

Authors
WENTLAND MP PERNI RB HUANG JI POWLES RG ALDOUS SC KLINGBEIL KM PEVERLY AD ROBINSON RG CORBETT TH JONES JL RAKE JB COUGHLIN SA
Citation
Mp. Wentland et al., CYCLIC VARIATIONS OF SR-233377 (WIN-33377) AND EFFECTS ON ANTITUMOR-ACTIVITY, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1345-1350
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
12
Year of publication
1996
Pages
1345 - 1350
Database
ISI
SICI code
0960-894X(1996)6:12<1345:CVOS(A>2.0.ZU;2-L
Abstract
Novel derivatives of SR 233377 (1, WIN 33377) where a pyrazolo ring fu sion has been incorporated at the 1- and 9-positions of the thioxantho ne ring displayed outstanding in vivo efficacy against the murine soli d tumor Pane 03 (T/C values of 0% with log cell kill greater than or e qual to 2.0). No relationship between structure and Pane 03 activity w as observed because all analogues studied were highly active. Copyrigh t (C) 1996 Elsevier Science Ltd