PROPERTIES OF NOVEL OLIGONUCLEOTIDE ANALOGS CONTAINING AN ACYCLIC NUCLEOSIDE AND A CARBAMATE LINKAGE

Authors
OBIKA S TAKASHIMA Y MATSUMOTO Y SHIMOYAMA A KOISHIHARA Y OHSUGI Y DOI T IMANISHI T
Citation
S. Obika et al., PROPERTIES OF NOVEL OLIGONUCLEOTIDE ANALOGS CONTAINING AN ACYCLIC NUCLEOSIDE AND A CARBAMATE LINKAGE, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1357-1360
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
12
Year of publication
1996
Pages
1357 - 1360
Database
ISI
SICI code
0960-894X(1996)6:12<1357:PONOAC>2.0.ZU;2-K
Abstract
Novel heterodimers containing an acyclic nucleoside and a carbarnate l inkage were incorporated into oligonucleotides, and the melting temper atures of the DNA-DNA and DNA-RNA duplexes as well as the nuclease res istance of the modified oligonucleotides were studied. Copyright (C) 1 996 Elsevier Science Ltd