STRUCTURE-ACTIVITY DEPENDENCY OF NEW BACTERIAL TRYPTOPHANYL TRANSFER-RNA SYNTHETASE INHIBITORS

Authors
WITTY DR WALKER G BATESON JH OHANLON PJ CASSELS R
Citation
Dr. Witty et al., STRUCTURE-ACTIVITY DEPENDENCY OF NEW BACTERIAL TRYPTOPHANYL TRANSFER-RNA SYNTHETASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1375-1380
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
12
Year of publication
1996
Pages
1375 - 1380
Database
ISI
SICI code
0960-894X(1996)6:12<1375:SDONBT>2.0.ZU;2-X
Abstract
Analogues of the aminoacyl tRNA synthetase inhibitor, indolmycin, have been synthesised in which the side chain methyl group is replaced by a wide range of substituents. Their antibacterial and enzyme inhibitor y potency is related to steric properties and conformational preferenc es. Copyright (C) 1996 Elsevier Science Ltd