IMPROVED SYNTHESIS OF OLIGONUCLEOSIDE METHYLPHOSPHONATE ANALOGS

Authors
HABUS I DEVLIN T IYER RP AGRAWAL S
Citation
I. Habus et al., IMPROVED SYNTHESIS OF OLIGONUCLEOSIDE METHYLPHOSPHONATE ANALOGS, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1393-1398
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
12
Year of publication
1996
Pages
1393 - 1398
Database
ISI
SICI code
0960-894X(1996)6:12<1393:ISOOMA>2.0.ZU;2-0
Abstract
Solid-phase synthesis using pent-4-enoyl nucleoside (PNT) phosphonamid ites allow for the facile preparation of oligonucleoside methylphospho nates, methylphosphonothioates and their chimeric analogs. With PNT ph osphonamidites, nucleobase and phosphate deprotection, as well as, cle avage from the support can all be accomplished by treatment of the sup port-bound oligonucleotide with NH4OH (28%, rt, 1 h). Copyright (C) 19 96 Elsevier Science Ltd