R. Roy et al., COMBINED GLYCOMIMETIC AND MULTIVALENT STRATEGIES FOR THE DESIGN OF POTENT SELECTIN ANTAGONISTS, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1399-1402
Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the
lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for c
opolymerization with acrylamide has been achieved. The resulting water
-soluble copolyacrylamide showed inhibition of binding of both L- and
E-selectins in the mu Molar range. Copyright (C) 1996 Elsevier Science
Ltd