COMBINED GLYCOMIMETIC AND MULTIVALENT STRATEGIES FOR THE DESIGN OF POTENT SELECTIN ANTAGONISTS

Authors
ROY R PARK WKC SRIVASTAVA OP FOXALL C
Citation
R. Roy et al., COMBINED GLYCOMIMETIC AND MULTIVALENT STRATEGIES FOR THE DESIGN OF POTENT SELECTIN ANTAGONISTS, Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1399-1402
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
12
Year of publication
1996
Pages
1399 - 1402
Database
ISI
SICI code
0960-894X(1996)6:12<1399:CGAMSF>2.0.ZU;2-Z
Abstract
Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for c opolymerization with acrylamide has been achieved. The resulting water -soluble copolyacrylamide showed inhibition of binding of both L- and E-selectins in the mu Molar range. Copyright (C) 1996 Elsevier Science Ltd