EPOMUSENIN-A AND EPOMUSENIN-B, 2 ACETOGENINS FROM FRUITS OF ROLLINIA-MUCOSA

Chromatography of an ethyl acetate extract of the fruits of Rollinia m ucosa led to the isolation of two new gamma-lactone acetogenins, epomu senins A and B, which are the first examples of the rare C-37-type ann onaceous acetogenins having an epoxide and a double bond along the ali phatic chain in place of the usual tetrahydrofuran moeity. The three k nown acetogenins, rolliniastatin-1, rolliniastatin-2 and squamocin wer e also isolated. The structures were established by means of one and t wo dimensional NMR experiments.