NOVEL SYNTHESIS OF 6,6-DIBROMO-2'-Z-CHLOROMETHYL AND 2'-Z-BROMOMETHYLANHYDROPENICILLINS FROM 6,6-DIBROMO 2-BETA-(CHLOROMETHYL) AND OMOMETHYL)-2-ALPHA-METHYL-PENAM-3-ALPHA-CARBOXYLIC ACID VIA ANHYDROPENICILIINREARRANGEMENT

Authors
DANELON GO MATA EG MASCARETTI OA
Citation
Go. Danelon et al., NOVEL SYNTHESIS OF 6,6-DIBROMO-2'-Z-CHLOROMETHYL AND 2'-Z-BROMOMETHYLANHYDROPENICILLINS FROM 6,6-DIBROMO 2-BETA-(CHLOROMETHYL) AND OMOMETHYL)-2-ALPHA-METHYL-PENAM-3-ALPHA-CARBOXYLIC ACID VIA ANHYDROPENICILIINREARRANGEMENT, Tetrahedron letters, 37(26), 1996, pp. 4431-4434
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
26
Year of publication
1996
Pages
4431 - 4434
Database
ISI
SICI code
0040-4039(1996)37:26<4431:NSO6A2>2.0.ZU;2-6
Abstract
We describe the preparation of isomerically pure 2'-Z-chloromethyl and 2'-Z-bromomethyl anhydropenicillins 2a and 2b, from 6,6-dibromo 2 bet a-(chloromethyl) and 2 beta-(bromomethyl)-2 alpha-methyl-penam-3 alpha -carboxylic acid through the Wolfe rearrangement of anhydropenicillins . Copyright (C) 1996 Elsevier Science Ltd