SYNTHESIS OF ARYLPIPERAZINES VIA PALLADIUM-CATALYZED AROMATIC AMINATION REACTION WITH UNPROTECTED PIPERAZINES

Authors
ZHAO SH MILLER AK BERGER J FLIPPIN LA
Citation
Sh. Zhao et al., SYNTHESIS OF ARYLPIPERAZINES VIA PALLADIUM-CATALYZED AROMATIC AMINATION REACTION WITH UNPROTECTED PIPERAZINES, Tetrahedron letters, 37(26), 1996, pp. 4463-4466
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
26
Year of publication
1996
Pages
4463 - 4466
Database
ISI
SICI code
0040-4039(1996)37:26<4463:SOAVPA>2.0.ZU;2-D
Abstract
A series of arylpiperazines were synthesized in moderate to good yield s by palladium-catalyzed coupling reaction of aryl halides with unprot ected piperazines. Very high regioselectivities were observed when usi ng 2-methyl or 2,6-dimethylpiperazine. Copyright (C) 1996 Elsevier Sci ence Ltd