ASYMMETRIC ALLYLIC ALKYLATION CATALYZED BY PALLADIUM COMPLEXES WITH NEW CHIRAL LIGANDS

A potential chiral tridentate ligand based on 2,6-disubstituted pyridi ne has been prepared and its palladium complexes have been used in asy mmetric allylic alkylation. Up to 75 % ee is achieved in the reaction between 1,3-diphenyl-2-propenyl acetate and dimethyl malonate. A contr ol experiment with a similar ligand without pyridine suggests that the bidentate diphosphine coordination is responsible for the asymmetric reaction with this potential tridentate ligand. Copyright (C) 1996 Els evier Science Ltd