M. Bogavac et al., OVARIAN-CARCINOMA - MODIFICATION OF T4 LYMPHOCYTES AFTER SURGERY AND DURING CHEMOTHERAPY, Journal of chemotherapy, 8(3), 1996, pp. 229-231
Objective: To examine the values of helper/inducer lymphocytes (T4), p
reoperatively, and during the chemotherapy, 1 and 3 months postoperati
vely in a prospective randomized study of women with cancer. The study
included 30 surgically-treated patients with ovarian cancer at the De
partment of Obstetrics and Gynecology in Novi Sad, Yugoslavia. In the
control group, 20 patients had no malignant ovarian tumor. Patients wi
th ovarian cancer, besides surgical treatment, were treated with chemo
therapy (CP protocol). Helper/inducer lymphocytes were defined by mono
clonal antibody - CD4, conducted by laser flow cytometry. The average
values of T4 lymphocytes in relation to control group (1.09+/-0.50), i
n IIIa, IIIb and IIIc stage of ovarian cancer decreased preoperatively
(0.55+/-0.26), but increased in stages Ia and Ic (1.12+/-0.57) and in
stage IV (0.31+/-0.51). Post surgery treatment (1 and 3 months) and d
uring chemotherapy (CP protocol), the average values of T4 lymphocytes
were lowered in relation to preoperative values.