PROTECTION OF THE INDOLE RING OF TRYPTOPHAN BY THE NUCLEOPHILE-STABLE, ACID-CLEAVABLE N-IN-2,4-DIMETHYLPENT-3-YLOXYCARBONYL (DOC) PROTECTING GROUP

Authors
KARLSTROM A UNDEN A
Citation
A. Karlstrom et A. Unden, PROTECTION OF THE INDOLE RING OF TRYPTOPHAN BY THE NUCLEOPHILE-STABLE, ACID-CLEAVABLE N-IN-2,4-DIMETHYLPENT-3-YLOXYCARBONYL (DOC) PROTECTING GROUP, Chemical communications, (12), 1996, pp. 1471-1472
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
12
Year of publication
1996
Pages
1471 - 1472
Database
ISI
SICI code
1359-7345(1996):12<1471:POTIRO>2.0.ZU;2-H
Abstract
The N-in-2,4-dimethylpent-3-yloxycarbonyl (Doc) group is presented as a new protecting group for tryptophan that is stable to nucleophiles a nd trifluoroacetic acid, suppresses alkylation side reactions and is c leaved by strong acid along with other protecting groups used in Boc s olid phase peptide synthesis.