GLYCOSIDASE-CATALYZED SYNTHESIS OF OLIGOSACCHARIDES - TRISACCHARIDES WITH THE ALPHA-D-GAL-(1-]3)-D-GAL TERMINUS RESPONSIBLE FOR THE HYPERACUTE REJECTION RESPONSE IN CROSS-SPECIES TRANSPLANT REJECTION FROM PIGSTO MAN

Authors
VIC G SCIGELOVA M HASTINGS JJ HOWARTH OW CROUT DHG
Citation
G. Vic et al., GLYCOSIDASE-CATALYZED SYNTHESIS OF OLIGOSACCHARIDES - TRISACCHARIDES WITH THE ALPHA-D-GAL-(1-]3)-D-GAL TERMINUS RESPONSIBLE FOR THE HYPERACUTE REJECTION RESPONSE IN CROSS-SPECIES TRANSPLANT REJECTION FROM PIGSTO MAN, Chemical communications, (12), 1996, pp. 1473-1474
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
12
Year of publication
1996
Pages
1473 - 1474
Database
ISI
SICI code
1359-7345(1996):12<1473:GSOO-T>2.0.ZU;2-C
Abstract
alpha-Galactosidases from Coffea arabica, Aspergillus niger and A. ory zae catalyse the transfer of alpha-galactosyl residues on to lactose t hioglycosides to give 1 --> 3 and 1 --> 6 linked trisaccharides, inclu ding an unusual branched trisaccharide 11 and the isoglobotriose glyco side 4, which, as 'linear B type 6', has been recognised as of the typ e responsible for the hyperacute rejection response in pig-to-man xeno transplantation.