EXTRA-COLUMN EFFECTS IN DETERMINATION OF RATE PARAMETERS BY THE CHROMATOGRAPHIC METHOD

It was shown that the sampling loop, detector and connecting elements in the chromatographic set-up for determination of transport parameter s by the dynamic method significantly influence the response peaks fro m columns packed with porous or nonporous particles. A method, based o n the use of convolution theorem, was developed which can take these e ffects into account, The applicability of this method was demonstrated on the case of axial dispersion in a single-pellet-string column (SPS R) packed with nonporous particles. It is possible to handle also resp onses from columns packed with porous particles by a similar procedure .