Mt. Thebault et al., SHORT-TERM CADMIUM INTOXICATION OF THE SHRIMP PALAEMON SERRATUS - EFFECT ON ADENYLATE METABOLISM, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 113(3), 1996, pp. 345-348
1. Shrimps were exposed for 96 hr to various concentrations of cadmium
under laboratory conditions. The LC(50) was around 4 ppm Cd in water,
which corresponded to 0.180 mu g/g wet weight of cadmium in tail musc
les. 2. The effect of various concentrations of cadmium on adenylates
was analyzed in tail muscles: At subletal cadmium concentrations, no v
ariation of ATP, ADP and of the adenylate sum occurred, while the AMP
concentration began to decrease from 0.06 ppm.At the LC(50) the ATP, A
DP and AMP concentrations dropped acutely, the ATP/ADP ratio increased
acutely. The apparent equilibrium constant of the adenylate kinase re
action increased significantly from 2 ppm Cd, indicating an impairment
in energetic metabolism. Cadmium intoxication did not influence the v
alue of the adenylate energy charge.