PROTECTIVE EFFECT OF DIETHYLDITHIOCARBAMATE ON MERCURY-INDUCED TOXICITY IN KIDNEY MITOCHONDRIA

Authors
REYESVIVAS H LOPEZMORENO F CHAVEZ E
Citation
H. Reyesvivas et al., PROTECTIVE EFFECT OF DIETHYLDITHIOCARBAMATE ON MERCURY-INDUCED TOXICITY IN KIDNEY MITOCHONDRIA, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 113(3), 1996, pp. 349-352
Citations number
24
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
113
Issue
3
Year of publication
1996
Pages
349 - 352
Database
ISI
SICI code
1367-8280(1996)113:3<349:PEODOM>2.0.ZU;2-D
Abstract
The protective effect of diethyldithiocarbamate on several functions o f kidney mitochondria, isolated from rats poisoned with mercury, was a nalyzed. The drug, administered at a concentration of 10 mg/kg body we ight to rats treated with a sublethal dose of Hg2+, for example, 2 mg/ kg body weight, prevented the mercury-induced damage on: a) transmembr ane potential, b) ATP synthesis, and c) Ca2+ accumulation. It is demon strated that such a protective effect of diethyldithiocarbamate is due to its ionophoretic properties on mercury.