EFFECTS OF AN ACUTE DOSE OF ETHANOL ON DOPAMINERGIC AND SEROTONERGIC SYSTEMS FROM RAT CEREBRAL-CORTEX AND STRIATUM

Authors
GILMARTIN E COLADO I FERNANDEZLOPEZ A FERNANDEZBRIERA A CALVO P
Citation
E. Gilmartin et al., EFFECTS OF AN ACUTE DOSE OF ETHANOL ON DOPAMINERGIC AND SEROTONERGIC SYSTEMS FROM RAT CEREBRAL-CORTEX AND STRIATUM, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 113(3), 1996, pp. 399-402
Citations number
32
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
113
Issue
3
Year of publication
1996
Pages
399 - 402
Database
ISI
SICI code
1367-8280(1996)113:3<399:EOAADO>2.0.ZU;2-7
Abstract
Intraperitoneal injection 10 min before sacrifice of 1.5 g ethanol/kg weight produced an increase in rat striatal. levels of homovanillic ac id (HVA) (p < 0.05) but did not affect the striatal concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT ) and 5-hydroxyindoleacetic acid (5-HIAA). A similar ethanol treatment led to decreases in 5-HT (p < 0.05) and 5-HIAA (p < 0.05) from cerebr al cortex (prefrontal and anterior cingulate areas). The results point to several ethanol-linked alterations in central serotonergic and dop aminergic systems.