EFFECTS OF INHALED NITRIC-OXIDE ON HYPOXIC PULMONARY VASOCONSTRICTIONIN DOGS AND A CASE-REPORT OF VENAE CAVAE SYNDROME

We investigated the effect of inhaled nitric oxide (NO) on hypoxic pul monary vasoconstriction (HPV) in dogs, by treating a dog suffering fro m venae cavea syndrome (VCS) and pulmonary hypertension (PH) with NO i nhalation. The increasing mean pulmonary arterial pressure (mPAP) indu ced by hypoxia was lessened significantly by NO inhalation. High PAP i n VCS also declined as a result of NO inhalation. These results sugges ted that inhaled NO can reverse HPV in dogs and prevent worsening PH d uring surgical extraction of heartworm in VCS.