ISATIN - A LINK BETWEEN NATRIURETIC PEPTIDES AND MONOAMINES

Citation
Ae. Medvedev et al., ISATIN - A LINK BETWEEN NATRIURETIC PEPTIDES AND MONOAMINES, Biochemical pharmacology, 52(3), 1996, pp. 385-391
Citations number
58
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
ISSN journal
00062952
Volume
52
Issue
3
Year of publication
1996
Pages
385 - 391
Database
ISI
SICI code
0006-2952(1996)52:3<385:I-ALBN>2.0.ZU;2-#
Abstract
Isatin is an endogenous indole with a distinctive distribution in brai n and tissues. In the brain, the highest levels have been found in the hippocampus (0.1 mu g/g), and an immunocytochcmical stain has shown s pecific localization within particular cells. In vitro, its most poten t known actions are as an inhibitor of monoamine oxidase B (IC50 simil ar to 3 mu M), and of atrial natriuretic peptide (ANP) receptor bindin g and ANP-induced guanylate cyclase (both with an IC50 similar to 0.4 mu M). In vivo, isatin administration (10-200 mg/kg) causes an increas e of monoamine neurotransmitter levels in the brain. Isatin is anxioge nic in animal models at doses of 10-20 mg/kg and sedative at higher do ses. Its anxiogenic effects are unlikely to be due to inhibition of mo noamine oxidase, but may possibly stern from interaction with the ANP system. Isatin may mediate a link between monoamines and the natriuret ic peptide system, and its analogues may provide new pharmacological t ools.