REGIONAL LOCALIZATION OF 2 MRX GENES TO XQ28 (MRX28) AND TO XP11.4-XP22.12 (MRX33)

Two genes responsible for a nonspecific form of X-linked mental retard ation (MRX28 and MRX33) were localized by linkage analysis with 40 hig hly polymorphic DNA markers situated along the entire the X chromosome , In family 1, the gene could be mapped within a 14-cM interval at Xq2 8, distal to the recombining marker DXS1113 (MRX28). The maximum LOD s core was 2.75, with DXS52 at phi = .0., In family 2, the gene was loca lized within a 30-cM interval at Xp11.4-22.12 between the recombining markers DXS365 and MAOB, including the DMD gene (MRX33). Maximum LOD s cores of 2.82 were obtained with markers DMD-STR49, DMD-DysII, CYBB, a nd DXS1068. (C) 1996 Wiley-Liss, Inc.