Recent evolutionary models have introduced ''small mutation rates'' as
a way of refining predictions of long-run behavior. We show that this
refinement effect can only be obtained by restrictions on how the mag
nitude of the effect of mutation on evolution varies across states of
the system. In particular, given any model of the effect of mutations,
any invariant distribution of the ''mutationless'' process is close t
o an invariant distribution of the process with appropriately chosen s
mall mutation rates.