Inhibitory effect of miso extracts on the melanogenesis in a highly pi
gmented clone (B 16-C 7) of cultured B16 mouse melanoma cells was stud
ied. The nondialyzate of hot water extracts from mise A (rice miso typ
e) had a slight inhibitory effect on the melanogenesis, but extracts f
rom miso B (barley miso type) and miso C (soybean mise type) inhibited
melanogenesis significantly. Suppression on melanogenesis by miso B e
xtract in cultured B 16-C 7 cells was shown to be reversible.