HUMAN GENETIC-VARIATION IN THE SIERRA DE GREDOS MOUNTAIN (CENTRAL SPAIN) - STUDY OF SEVERAL POLYMORPHISMS

The variation in the third component of human complement (C3) and oros omucoid (ORM1) serum proteins, and 6-phosphogluconate dehydrogenase (6 PGD), adenosine deaminase (ADA), esterase D (ESD), and acid phosphatas e (ACP1) red cell enzymes was examined in two samples from autochthono us populations living on either side of the Sierra de Gredos range in Central Spain. These results support only a moderate differentiation b etween Gredos subpopulations, which is discussed in relation to other Iberian Peninsula groups. Allele frequencies in Gredos show a remarkab le heterogeneity as contrasted with other Iberian populations for most of the markers examined; relatively high C3S, ORM1*F, ADA*1, ESD*2, and ACP1C gene frequencies are characteristics of Gredos samples. Thi s differentiation was more marked for the Northern Gredos population a nd could be related to the geographical peculiarities of this region.