Background: The fibroepithelial polyp (FEP) is a common cutaneous lesi
on that is often removed for medical or cosmetic reasons. We examined
the utility of submitting clinically diagnosed FEPs for routine micros
copic examination. Design: We reviewed 11 500 consecutive cutaneous pa
thology reports. Materials submitted with the clinical diagnosis of FE
P or a synonym were reviewed and the histopathologic slides were exami
ned. A comparison group of specimens submitted with the clinical diagn
osis of melanocytic nevus was reviewed. Setting: The biopsy reports we
re generated at a regional non-hospital-based dermatopathology laborat
ory providing service to physicians (dermatologists and nondermatologi
sts) practicing ambulatory medicine predominantly within a 4-state reg
ion (Ind, Ky, Tenn, and WVa). Results: Of 1335 clinical specimens subm
itted as FEPs, there were 5 malignant tumors. In the comparison group
of 697 clinically diagnosed melanocytic nevi, there were 6 malignant t
umors. In comparison with clinically diagnosed melanocytic nevi, the l
ikelihood that a lesion clinically diagnosed as FEP would be a maligna
nt tumor on histological examination is very low (relative risk, 0.4).
None of the lesions clinically diagnosed as FEPs by dermatologists pr
oved to be malignant. Conclusions: Our data suggest there is an extrem
ely low prevalence of malignancy in lesions clinically diagnosed as FE
Ps. We conclude that cutaneous lesions diagnosed as typical FEPs by de
rmatologists need not be submitted for microscopic examination.