The debate over alternative regimes for currently illicit psychoactive
substances focuses on polar alternatives: harsh prohibition and sweep
ing legalization. This study presents an away of alternatives that lie
s between these extremes. The current debate lacks an explicit and inc
lusive framework for making comparative judgments. In this study, we s
ketch out such a framework, as a reminder of possible policy levers an
d their costs and benefits that might otherwise be neglected or go unr
ecognized. The framework identifies a range of pharmacological and eco
nomic characteristics of substances, potential harms and their bearers
, and the sources of those harms, including drug use, trafficking, law
enforcement, and illegal status per se. The framework highlights the
difficulty of making objective, rigorous comparisons among regimes, bu
t we believe that it can serve a useful heuristic role in promoting mo
re constructive debate and identifying fruitful questions for research
.