USE OF THE EQUILIBRIUM-DISPERSIVE MODEL OF NONLINEAR GAS-CHROMATOGRAPHY FOR THE MODELING OF THE ELUTION BAND PROFILES IN THE PREPARATIVE-SCALE GAS-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS
Du. Staerk et al., USE OF THE EQUILIBRIUM-DISPERSIVE MODEL OF NONLINEAR GAS-CHROMATOGRAPHY FOR THE MODELING OF THE ELUTION BAND PROFILES IN THE PREPARATIVE-SCALE GAS-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS, Journal of chromatography, 734(2), 1996, pp. 289-296
Citations number
17
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
The equilibrium-dispersive model of chromatography is applied to the s
tudy of enantioselective separations of methyl 2-chloropropionate in g
as chromatography. The single-component and competitive bi-Langmuir is
otherm equations that describe the sorption behavior of single enantio
mers and racemates, respectively, are utilized by the equilibrium-disp
ersive model to predict the elution band profiles of single-component
and binary mixture samples. The measured and the calculated band profi
les are compared both for the analytical open tubular column used to a
cquire the isotherm data and for the 1 mX22.5 mm I.D. preparative pack
ed column, followed by the comparison of the enantiomeric purity vs. p
roduction curves for both the measured and the simulated systems.