USE OF THE EQUILIBRIUM-DISPERSIVE MODEL OF NONLINEAR GAS-CHROMATOGRAPHY FOR THE MODELING OF THE ELUTION BAND PROFILES IN THE PREPARATIVE-SCALE GAS-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS

The equilibrium-dispersive model of chromatography is applied to the s tudy of enantioselective separations of methyl 2-chloropropionate in g as chromatography. The single-component and competitive bi-Langmuir is otherm equations that describe the sorption behavior of single enantio mers and racemates, respectively, are utilized by the equilibrium-disp ersive model to predict the elution band profiles of single-component and binary mixture samples. The measured and the calculated band profi les are compared both for the analytical open tubular column used to a cquire the isotherm data and for the 1 mX22.5 mm I.D. preparative pack ed column, followed by the comparison of the enantiomeric purity vs. p roduction curves for both the measured and the simulated systems.