DURATION OF FILGRASTIM MOBILIZATION AND APHERESIS YIELD OF CD34(+) PROGENITOR CELLS AND LYMPHOID SUBSETS IN NORMAL DONORS FOR ALLOGENEIC TRANSPLANTATION

Seventy-seven normal donors underwent leukapheresis for peripheral blo od progenitor cell collection beginning on day 4 (n = 45) or day 5 (n = 32) of filgrastim mobilization (12 mu g/kg/d). The two groups were c omparable for age, weight, blood volumes processed during leukapheresi s and target CD34(+) cell dose to be collected. The day 5 schedule all owed a more consistent achievement of the target cell dose with one ap heresis (P = 0.005) and resulted in the initial collection of a signif icantly larger number of CD34(+) cells (P = 0.009). There was no stati stically significant difference in the leukapheresis yield of lymphoid subsets and natural killer cells.