NOVEL TRITERPENE SULFATES FROM FUSARIUM-COMPACTUM USING A RHINOVIRUS-3C PROTEASE INHIBITOR SCREEN

Authors
BRILL GM KATI WM MONTGOMERY D KARWOWSKI JP HUMPHREY PE JACKSON M CLEMENT JJ KADAM S CHEN RH MCALPINE JB
Citation
Gm. Brill et al., NOVEL TRITERPENE SULFATES FROM FUSARIUM-COMPACTUM USING A RHINOVIRUS-3C PROTEASE INHIBITOR SCREEN, Journal of antibiotics, 49(6), 1996, pp. 541-546
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
6
Year of publication
1996
Pages
541 - 546
Database
ISI
SICI code
0021-8820(1996)49:6<541:NTSFFU>2.0.ZU;2-4
Abstract
Two novel triterpene sulfates have been isolated from Fusarium compact um by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by counter current and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.