ASCOSTEROSIDE, A NEW ANTIFUNGAL AGENT FROM ASCOTRICHA-AMPHITRICHA .1.TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITIES

Authors
GORMAN JA CHANG LP CLARK J GUSTAVSON DR LAM KS MAMBER SW PIRNIK D RICCA C FERNANDES PB OSULLIVAN J
Citation
Ja. Gorman et al., ASCOSTEROSIDE, A NEW ANTIFUNGAL AGENT FROM ASCOTRICHA-AMPHITRICHA .1.TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 49(6), 1996, pp. 547-552
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
6
Year of publication
1996
Pages
547 - 552
Database
ISI
SICI code
0021-8820(1996)49:6<547:AANAAF>2.0.ZU;2-R
Abstract
Ascosteroside, a novel antifungal compound, was isolated from the cult ure broth of Ascotricha amphitricha. This compound is an alpha-linked glycoside of a lanostane type triterpenoid. It is active against yeast s such as Candida albicans and Saccharomyces cerevisiae and against fi lamentous fungi but shows no activity against bacteria. It is not toxi c to mammalian cells at concentrations up to 150 mu M. In a mouse mode l, the compound afforded protection comparable to that of ketoconazole .