EXPRESSION PATTERN OF ACTIVATION AND ADHESION MOLECULES ON PERIPHERAL-BLOOD CD4(-LYMPHOCYTES IN RELAPSING-REMITTING MULTIPLE-SCLEROSIS PATIENTS - A SERIAL ANALYSIS() T)

We studied the expression of various cell surface molecules (CD25, CD2 8, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4(+) T-cell s in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthe rmore, changes in the expression pattern of these surface markers duri ng intervals of increased disease activity, which was measured by gado linium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Altho ugh several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.