AMYLOIDTUMORS OF THE LUNG - AN IMMUNOCYTOMA

Amyloid tumors are nodular amyloid depositions usually limited to one organ, which often develop without a known cause. In most cases they m ay be observed as being situated in the lung, the larynx, the skin, th e urinary bladder and in the region of the orbita, and are restricted to these organs. In the present study, we report on two cases of pulmo nal amyloid tumors which after immunohistochemical investigation revea led a clonal evolution of light chain restricted plasma cells and lymp hocytes corresponding to a localized primary extranodal lymphoplasmacy tic immunocytoma, with only few vital tumor cells among abundant tumor -shaped amyloid. Additionally, using polymerase chain reaction (PCR) t o investigate IgH gene rearrangement, clonality of the tumor cells cou ld be demonstrated in both cases.