IMMUNOLOCALIZATION OF KERATAN SULFATE, CHONDROITIN-4-SULFATE, AND CHONDROITIN-6-SULFATE IN PERIPROSTHETIC BREAST CAPSULES EXHIBITING SYNOVIAL METAPLASIA
Ds. Raso et Ba. Schulte, IMMUNOLOCALIZATION OF KERATAN SULFATE, CHONDROITIN-4-SULFATE, AND CHONDROITIN-6-SULFATE IN PERIPROSTHETIC BREAST CAPSULES EXHIBITING SYNOVIAL METAPLASIA, Plastic and reconstructive surgery, 98(1), 1996, pp. 78-82
The distribution of various proteoglycans and basement membrane compon
ents within 10 breast capsules with synovial metaplasia was assessed i
mmunohistochemically. Immunoreactive keratan sulfate and chondroitin-4
-sulfate were present in many of the synovial metaplasia lining cells,
suggesting active secretion of these proteoglycans into the intrapros
thetic space. In contrast, chondroitin-6-sulfate was confined to the e
xtracellular matrix of the underlying supporting fibrous capsule. Type
IV collagen and laminin were not associated with the synovial metapla
sia lining, thus confirming the absence of a basement membrane, as pre
viously indicated by morphologic analysis. As with tendon reconstructi
on, the development and maintenance of a syovial metaplasia lining tha
t secretes lubricating factors such as proteoglycans may be beneficial
for decreased capsular contracture.