A PROLACTIN-SECRETING TUMOR IN A PATIENT WITH KLINEFELTERS-SYNDROME -A CASE-REPORT

We report the case of a patient with Klinefelter's syndrome who develo ped a prolactin (PRL)-secreting tumor. The patient developed headaches , visual alterations and also symptoms of hypogonadism despite appropr iate testosterone (T) replacement therapy, The diagnosis of hyperprola ctinemia was then suspected. The laboratory findings confirmed the hyp othesis, showing high levels of serum PRL. The patient was initially t reated with oral bromocriptine, and afterwards with the injectable for m. There was a marked decrease in PRL levels and in tumor size. Althou gh some neoplasms, like breast carcinoma and germ cell tumors, are kno wn to occur more frequently in patients with Klinefelter's syndrome, a n association with PRL-secreting tumor has not been reported yet. In c onclusion, symptoms of hypogonadism in patients with Klinefelter's syn drome receiving appropriate T replacement therapy can suggest the pres ence of hyperprolactinemia.