MICELLAR ELECTROKINETIC CHROMATOGRAPHY PERSPECTIVES IN DRUG ANALYSIS

Micellar electrokinetic chromatography (MEKC) has become a popular mod e among several capillary electromigration techniques. Most drug analy ses can be performed by using MEKC because of its wide applicability. Enantiomer separation, separation of closely related peptides and isot opic compounds, separation of very complex mixtures, determination of drugs in the biological samples, etc., can be successfully achieved by MEKC. This review surveys typical applications of MEKC analysis. Rece nt advances in MEKC, especially with pseudo-stationary phases, are des cribed. Modes of electrokinetic chromatography including MEKC, a separ ation theory of MEKC and selectivity manipulation in MEKC are also bri efly mentioned.