CAPILLARY ELECTROPHORESIS OF CARDIOVASCULAR DRUGS

This review surveys the use of capillary electrophoresis for the analy sis of cardiovascular drugs. Each section presents examples of separat ions according to the class of the cardiovascular agent. The classes p resented are beta-adrenergic antagonists (beta-blockers), acetylcholin esterase inhibitors, angiotensin-converting enzyme inhibitors, dieuret ics, alpha-adrenergic antagonists, calcium channel blockers, cardiac g lycosides, hypolipidemics (HmG-CoA reductase inhibitors and fibric aci d), vasodilators and sodium channel blockers. Examples of the separati on modes discussed include capillary electrophoresis, micellar electro kinetic chromatography using many additives (e.g. sodium dodecyl sulfa te, cyclodextrins, bile salts, proteins, oligosaccharides) and isotach ophoresis.