SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY ELECTROPHORESIS .3. BETA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT

Enantiomer separation by capillary zone electrophoresis was studied fo r a set of 34 chiral drugs. Keeping the concentration of beta-cyclodex trin as a chiral solvating agent as constant as possible led to the se paration of seven enantiomeric pairs. Carvedilol, Tetryzoline, Tropica mide and Zopiclone gave a baseline separation, Chlorphenamine, Ketamin e, and Orciprenaline a partial separation. Statistical analysis reveal ed that the best separation factors were observed for a medium degree of interaction with the cyclodextrin. A theory explaining this effect provides a helpful guideline for further optimization.